Clinical Handbook of Psychological Disorders, Sixth Edition — A Step-by-Step Treatment Manual
The Clinical Handbook of Psychological Disorders, Sixth Edition is the definitive guide to evidence-based treatment for a wide range of mental health conditions. Edited by leading clinician-scientist David H. Barlow, this edition brings together top experts to deliver detailed, step-by-step protocols for diagnosis, assessment, case formulation, and therapy — making it essential for students, trainees, and experienced practitioners alike.
Spanning 822 pages, the handbook covers a broad spectrum of disorders — from anxiety and mood disorders to personality, psychotic, substance use, sleep, pain, eating, and relationship problems. Each chapter combines the latest science with real-world clinical vignettes to answer the all-important question: “How do I treat this?”
This 6th edition has been revised and expanded: existing chapters have been updated to reflect the latest empirical findings and clinical practices; and new content includes a chapter on “process-based therapy” for social anxiety, a transdiagnostic approach for self-injurious thoughts and behaviors, and a section on chronic pain.
Why This Handbook Matters
Comprehensive & authoritative: Covers nearly every major psychiatric disorder often seen in practice (anxiety, depression, bipolar disorder, schizophrenia, substance use, eating disorders, sleep disturbance, chronic pain, relationship distress, and more).
Practical, clinically oriented: Provides detśailed treatment protocols, case examples, session transcripts, and guidance on setting, context, therapist and client variables — bridging the gap between theory and real-world therapy.
Up-to-date & evidence-based: Reflects the latest advances in clinical psychology, including “third-wave” approaches and transdiagnostic strategies — making it a current, reliable reference.
Ideal for varied audiences: From graduate students and trainees to seasoned clinicians and researchers — whether for study, teaching, supervision, or direct practice.












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